Powerful technology details elasticity of brain tumors – Florida News Times

A team led by researchers at Will Cornell Medical, New York’s Genome Center, Harvard Medical School, Massachusetts General Hospital, MIT and Harvard Bron Institute show thousands of individual cells from a patient’s brain tumor in an unprecedented way. He did. The findings, along with the methods developed for those findings, represent significant advances in cancer research and ultimately lead to better ways to identify, control and treat cancer. There is a possibility.

Researchers reported September 30 Natural Genetics, Used advanced techniques to model gene mutations, gene activity, and gene activity patterns in DNA, called metastasis in individual tumors. The cell was a sample of patients with the most common type of brain tumor. In this way, they mapped the behavior or “condition” of specific tumor cells in gliomas and identified important program signals that seemed to change the cells of the gliomas from one condition to another. .. In general, these program signs have the potential to target future medications.

Researchers have combined single-cell methods with molecular clock technology to create sample tumor cells that form “ancestral trees” and show the history of empirical changes.

Will Cornell Medicine, associate professor of hematology and oncology, says, “Like a time machine, you can take a sample of the tumor and list how it is progressing.” Sandra and Edward Meyer Cancer Center, and senior member of the New York Genome Center.

Dr. Mario Sva, a pathologist at Massachusetts General Hospital and an associate professor of pathology at Harvard Medical School, is a member of MIT and the Harvard Broadcasting Institute.

Tuberculosis cells are usually identified individually but not individually, and in relatively simple ways, for example, by their cell type and the receptors on them. Dr. Landow, however, has been a pioneer in the use of the “single-cell multi-omix” method, in which he described the tumor cells individually and in more detail.

The new study uses not only genetic sequences and textual information, but also the first three-layer method of recording epigenetic transcriptional control metastases directly from patients in individual tumor cells. Scientists have found an average of more than 100 tumor cells in seven patients with IDH mutant gliomas and seven patients with more severe IDH mutations in the wild. Sample is taken.

Both cancer cells are found in four different states, from stem cell-like states to mature brain cell-like states. They also identified clear DNA metalization that appears to explain the transition between these states. Such patterns may be disruptive to future therapies to prevent such changes in state and delayed tumor growth.

Researchers take an important snapshot of the cell’s tumor cell status, but they calculate the fluorescein tree for each cell based on changes in DNA metastasis that occur over time. I, in turn, developed a molecular clock system. History of various conditions from the origin of the tumor.

The phlegmite tree has a higher “plasticity” between the stem-like and mature regions, especially in cells with low glomerulomas. It turned out that it was easy to switch.

“The wild-type structure of the IDH wild-type globulusoma allows the cells to regenerate from the mature pool of mature cells. Landau Laboratory.

The findings provide a general insight into glioma variability. It is this understanding that develops better methods to identify, manage, monitor, and treat gliomas.

Researchers are now planning to use a single-celled multi-molecular approach to study how glyceum reacts to different therapies. In principle, he said, this approach could be used to study any type of development. Tumors, or even age-related genetic changes in healthy tissue.